The Circadian Sync: Understanding SR-9011 SR-9011 is a potent, synthetic REV-ERB agonist that shares a similar pharmacological profile with its predecessor, SR-9009, but is often studied for its refined binding affinity and stability. It targets the REV-ERB$\alpha$ and REV-ERB$\beta$ nuclear receptors, which are essential components of the mammalian “molecular clock.” In laboratory research, SR-9011 is utilized to explore how the modulation of these receptors can shift cellular metabolism toward increased energy expenditure and optimized nutrient partitioning. Mechanism of Action: SR-9011 operates by binding to REV-ERB receptors, which are transcription factors that suppress the expression of specific genes. By activating these receptors, SR-9011 influences the circadian rhythm—the internal 24-hour cycle that regulates sleep, wakefulness, and metabolic activity. This activation leads to a marked increase in mitochondrial count and metabolic rate within skeletal muscle. Furthermore, it downregulates the genes involved in lipid storage and glucose production in the liver. The compound undergoes hepatic metabolism through oxidation and conjugation, with primary clearance occurring via renal and biliary pathways. Technical Specifications: Chemical Name: 3-[[[4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide CAS Number: 1379686-29-9 Molecular Formula: $C_{23}H_{31}ClN_{4}O_{3}S$ Molecular Weight: $479.03 \, g/mol$ Purity: >99% (HPLC Verified) Form: Oral Capsules Applications in Human Research: The multifaceted metabolic effects of SR-9011 make it a premier candidate for several research fields: Endurance and Performance: Research focuses on the compound’s ability to significantly increase oxygen consumption and exercise capacity in experimental models. Adipose Tissue Reduction: Studies investigate SR-9011’s role in accelerating fat oxidation and preventing the formation of new fat cells (adipogenesis). Circadian Rhythm Stability: Researchers utilize the compound to study the mitigation of “jet lag” or shift-work-related metabolic dysfunction by re-syncing the molecular clock. Inflammation & Cardiovascular Health: Analyzing the compound’s impact on reducing systemic inflammatory markers and improving cholesterol profiles. The Swiss Chems Quality Standard When you look for SR-9011 for sale, verifying the exact molecular structure is critical. Many lower-grade products lack the stability required for consistent REV-ERB modulation. At Swiss Chems, we guarantee that our SR-9011 is strictly third-party lab tested for purity and potency. Our capsules are produced in a clinical-grade environment, ensuring they are free from heavy metals, unreacted precursors, and synthetic fillers. Buy online today from the Official Swiss Chems website and ensure your research is conducted with the most effective metabolic modulators on the market.
